6 Best NMN Supplements To Buy In 2024
NMN is one of the most popular supplements in the anti aging community. The
global Nicotinamide Mononucleotide (NMN) market was valued at US$ 98.5 million
in 2019 and it is expected to reach US$ 296.5 million (R) by the end of 2026, growing at a CAGR (Compound Annual Growth Rate) of 7.3%
during 2021-2026.
NMN is the precursor to NAD, which our cells use to power metabolic activity. In other words, NAD is essential for our cells to generate energy and thrive.
By middle age, our NAD levels have plummeted to half that of our youth. And this decline has been linked to various age-related diseases. The hope is that NMN, being the direct precursor to NAD, can boost levels and extend longevity.
What actually is NMN?
NMN is short for Nicotinamide mononucleotide and it's the precursor to NAD
(Nicotinamide adenine dinucleotide). In fact, two NMN molecules combined
together make NAD.
But NMN is actually one of many intermediary molecules before the formation of NAD.
In fact, it all starts with vitamin B3, also called Niacin or Nicotinamide.
Our cells combine Vitamin B3 with sugar. This compound is also called Nicotinamide Riboside (NR)
The next step is the addition of phosphate to NR. This new compound is called NMN as we know it. In other words, NMN = vitamin B3 + sugar + phosphate
Finally, two NMNs are combined together to form NAD.
So our cells naturally manufacture NMN as part of the process of making NAD.
In summary, NMN is an intermediary molecule in the pathway to producing NAD. Our cells naturally produce NMN from vitamin B3. NAD levels rise by taking NMN supplements because it's the direct precursor and circumvents the need for the initial two steps in the pathway to NAD production.
But NMN is actually one of many intermediary molecules before the formation of NAD.
In fact, it all starts with vitamin B3, also called Niacin or Nicotinamide.
Our cells combine Vitamin B3 with sugar. This compound is also called Nicotinamide Riboside (NR)
The next step is the addition of phosphate to NR. This new compound is called NMN as we know it. In other words, NMN = vitamin B3 + sugar + phosphate
Finally, two NMNs are combined together to form NAD.
So our cells naturally manufacture NMN as part of the process of making NAD.
In summary, NMN is an intermediary molecule in the pathway to producing NAD. Our cells naturally produce NMN from vitamin B3. NAD levels rise by taking NMN supplements because it's the direct precursor and circumvents the need for the initial two steps in the pathway to NAD production.
6 Best NMN Supplements 2024
While NMN is considered one of the most promising anti-aging ingredients,
it is not the only one available. Other ingredients, such as Resveratrol,
Quercetin, Fisetin, and Spermidine, are also believed to have anti-aging
properties.
However, taking all of these ingredients separately can be costly and impractical, as it would require taking numerous pills each day. That's why many top NMN supplements include a blend of other longevity ingredients to cover all bases.
There are numerous customer reviews of NMN supplements available online, but we have curated a selection of helpful ones below. Check out our recommended list of the best NMN and NAD booster supplements.
ProHealth Longevity NMN Pro Review:
- Unlike NMN, the key ingredient Niagen was successfully notified
two times as an NDI (New Dietary Ingredient) and reviewed as GRAS
(Generally Recognized As Safe) under the United States
notification programs.
Trusted by 12 U.S. National teams and many professional sports teams,
Thorne research provides safe, effective products free of
contamination. If you can’t (or don’t want to) risk accidentally
consuming banned substances, Thorne’s got you covered.
Can NMN truly reverse aging? In a 2013 Harvard study, the
Harvard scientists observed that “NMN was able to mitigate
most age-related declines in mice,” and that “treatment of
old mice with NMN reversed all of these biochemical aspects
of aging.” The study concluded that “enhancing NAD+
biosynthesis by using NAD+ intermediates, such as NMN and NR
(Nicotinamide Riboside), is expected to ameliorate
age-associated physiological decline”.
This has precipitated dozens of studies since that are focused on investigating NMN supplementation to treat cardiovascular disease, diabetes, obesity, life extension, cancer, Alzheimer’s disease, Parkinson’s disease, and many more.
A 2022 study on human subjects concluded that Oral Administration of
Nicotinamide Mononucleotide (NMN) Is Safe and Efficiently
Increases Blood Nicotinamide Adenine Dinucleotide (NAD)
Levels.
1. Anti-aging effects: Some studies have suggested that NMN may help improve cellular health, reduce oxidative stress, and potentially have anti-aging effects.
2. Improved insulin sensitivity: NMN has been shown to improve insulin sensitivity and glucose metabolism.
3. Improved cardiovascular health: NMN has been shown to improve cardiovascular function and reduce oxidative stress in the heart, which may help support overall heart health.
4. Enhanced exercise performance: Some studies have suggested that NMN supplementation may help improve exercise performance and recovery in animals.
Editor's Note: In February 2022, another third-party investigation
uncovered tens of thousands of fake supplements sold on Amazon. Many of these included NMN.
We don’t know if he still takes these supplements, or whether he takes additional supplements that are not included on this list.
For example, in his book Lifespan, he mentions on page 304 that he takes NMN and resveratrol every morning, often mixed in his yogurt.
As research grows, it is likely to become clearer that NMN and NR
may have differing benefits depending on the part of the body and
their use. Where NMN transporters are found, they could make one
more preferable over the other. NMN has also been found to improve
insulin activity and production which could help to accelerate
metabolisms and make the body more glucose tolerant.
• Vitamin B3 rich foods: Foods that are high in niacin (vitamin B3) can help increase NAD+ levels in the body. Good sources of niacin include yeast, beef liver, poultry, fish, and whole grains.
• Leafy greens: Leafy greens, such as spinach and kale, are rich in folate, which can help increase NAD+ levels in the body.
It is important to note that foods which are high in NAD precursors do not necessarily increase NAD or NMN levels. Despite having an abundance of NAD precursors in your diet, your cells can use these nutrients for other processes and may not use them to produce NMN and then NAD.
On the other hand, NMN supplements push your cells to produce more NAD which has been shown in several animal and a few human studies.
With so many different supplements on the market claiming to be the best, it's hard to know which one is worth investing in. Realistically, there are only a few things that really matter:
1. Purity
The best NMN supplements use 98% purity NMN. It's as simple as that, always look for this level and nothing less should make the cut. After all, it's obvious that we all want a supplement that contains as much of the active ingredient as possible.
2. Dosing
There is no official recommended dose of NMN. It's a relatively new supplement and most brands contain between 250mg - 750mg per serving which is based on the limited amount of research on this ingredient. David Sinclair openly says that he takes 1000mg of NMN a day which is a relatively high dose.
A recent study published in February 2023 tested daily NMN at doses of 300mg, 600mg, and 900mg over a 60-day period in healthy adults of 40-65 years old.
There were no side effects reported and they found that NAD levels increased in all of these doses. It's important to highlight this was a small study of only 80 individuals and the study only ran for 60 days so it's not clear what the long-term outcomes will be. There are a lot of unknowns when it comes to NMN dosing and you need to decide what feels right for you. (1 )
3. Quality
Quality is one of the more challenging things to determine when it comes to choosing an NMN supplement. Taking a close look at the supplement facts table is a good place to start. The best NMN supplements aim to keep the formula as clean as possible. They avoid ingredients like magnesium stearate, artificial fillers and ensure that the capsules are sustainably vegan. Look out for "other ingredients" on the product label and you'll quickly realize if you're looking at a high-quality NMN supplement or not.
How long does it take for NMN to start working?
There are a handful of studies that show taking NMN can boost NAD levels within a few weeks. A study we mentioned earlier saw a measurable rise in blood NAD levels after just 30 days.
In reality, NMN supplements are likely to boost NAD levels sooner than this.
But the time it takes for biological benefits to be seen is not yet known in humans. It's currently under investigation and more information will come out in the next few years.
Some people report having more energy and better skin, but most people won't actually 'feel' anything. It's more so that the benefits are occurring at a cellular level which you won't necessarily be able to consciously notice.
Is NMN just vitamin B3?
The answer to this question is now obvious from the above. NMN is vitamin B3 + sugar + phosphate. So it's not just vitamin B3. It's two steps further along in the chain.
At this stage, most people think that they'll just take Vitamin B3 and that will eventually form NMN. But the issue is that a lot of energy is required to go from vitamin B3 to NMN and our cells won't naturally go down this route.
What are the side effects of taking NMN supplements?
As with all things NMN related, there isn't much solid information on NMN side effects. There are only a handful of studies using NMN in humans. Side effects are seldom reported and doses up to 1000mg are generally well-tolerated.
For example, one study gave 250 mg/day of NMN for 10 weeks to 25 prediabetic women who were overweight or obese without any adverse effects. (2)
But this does not mean that you won't experience any side effects. As with any supplement, the risk of experiencing a negative reaction is always possible. So always discuss this with your physician, especially if you have any other medical conditions and taking any medicines.
Is NMN safe to take long term?
It's really important to understand that there are no long term studies into NMN supplementation. Most studies run for a maximum of a few months. So there's a big question mark over the safety profile of long term NMN usage.
Although no red flags have been raised with respect to NMN just yet, it's very early days. It will be years before we know if NMN is safe to take long term and which dose is best.
So you have to decide for yourself whether taking NMN supplements is worth it.
At what age should you take NMN supplements?
There's no hard and fast rule for when you should start taking NMN supplements.
Hardcore advocates of NMN will say the sooner the better!
NAD levels decline at different rates depending on what organ you're looking at. But it's generally believed that NAD levels drop by about 50% every 20 years.
So whether you're in your 30s or 70s, the question of when you should start taking NMN supplements is not relevant. If you've done your research and want to take
NMN supplements, the best time to start is arguably now.
Can NMN reverse wrinkles?
NMN supplements are not the magic elixir for youth. It's effects are largely seen on a cellular level and the majority of people won't visibly see any changes in their exterior appearance.
With that said, some people have reported smoother skin, fewer wrinkles and reduction in grey hairs. But it's not been properly proven in research studies and it could be a placebo effect.
It is also important to keep in mind that wrinkles are a natural part of the aging process, and are caused by a variety of factors including genetics, exposure to the sun and other environmental factors, and lifestyle choices such as smoking and poor diet.
It's best to think of NMN supplements as a longevity aid that works on a cellular level. Rather than taking them with the aim of having a more youthful appearance.
How can I increase my NMN naturally?
In your quest for the best NMN supplement, you may be thinking you also want to try and increase your levels naturally.
In reality, what you're trying to increase is your NAD levels. And NMN supplements are only one of many ways in which you can boost your NAD levels.
1. High intensity interval training
All exercise is good. But studies have shown that high intensity interval training (HIIT) is particularly good. It's not suitable for everyone because the intensity can have negative health implications for people with underlying conditions (for example heart arrhythmias). (3 )
HIIT can be achieved with many different types of exercise. For example:
- short sprint bursts followed by a light jog
- Spin classes (i.e short bursts of vigorous cycling followed by lower intensity cycling)
- HIIT classes (which involve various bodyweight exercises)
But even something like doing jumping jacks intensely or high knee raises at home achieves a similar effect.
The theory is that the bursts of high activity mimic "threat" or "danger" which would have been a frequent occurrence as humans evolved on the savannahs of Africa hundreds of thousands of years ago. And this activates certain longevity genes.
But there's a sweet spot because if it's pushed too far, HIIT can be damaging. So it's best to start after a discussion with your physician and a trainer to assess your level.
2. Fasting
Going for prolonged periods without any calories has been shown to activate genes that extend longevity at a cellular level. When food is scarce, the body is tricked into thinking that "hard times are coming". In other words, the cells start activating genes that increase NAD levels in preparation for the perceived hardship. (4 )
A common entry-level regimen is the 18:6 Intermittent fasting. Essentially, only eating in a 6-hour window and having no calories at all for 18 hours. Some people just opt to eat once a day and others fast for several days at a time.
The studies show that the more aggressive regimens have the most health benefits. But of course, it's extremely difficult to maintain and definitely not suitable for the majority of people. But the entry-level fasting regimens are not too challenging. As always, speak to your doctor first.
3. Heat and cold shock
You've probably guessed the theme by now. Your cells respond to stress by activating protective genes. So the same applies to heat and cold shock. For example, using ice baths.
Obviously, there's a fine line between experiencing health benefits and harm. Pushing any of this too far can have serious health consequences. So if you're thinking of trying any of the above, you really must speak to a trained professional to get advice on how to start.
Is NMN hard on the liver?
There is currently no evidence to suggest that NMN is harmful to the liver. In fact, some studies have suggested that NMN may have a positive effect on liver health, as it has been shown to improve insulin sensitivity and reduce oxidative stress in liver cells.
However, it is important to keep in mind that NMN is a relatively new molecule and more research is needed to fully understand its effects on the body, including its impact on the liver.
Which is better: NMN or resveratrol?
It's hard to compare NMN and Resveratrol as they are completely different compounds with unique properties. Professor David Sinclair is an advocate of both and takes them daily.
Resveratrol is a natural compound formed in various foods such as grapes, red wine, and some berries. It's an antioxidant and anti-inflammatory compound in its own right. It has also been shown to increase NAD levels indirectly by activating certain pathways which are different to how NMN works.
In summary, NMN and resveratrol work differently and you can't directly compare them. That's why the best resveratrol supplements often combine these powerful ingredients together.
Why are NMN supplements expensive?
NMN supplements can be expensive for several reasons:
1. Production costs: NMN is a relatively new molecule and the production process can be complex and time-consuming, which pushed the price up.
2. Limited supply: NMN is not found in large quantities in natural food sources, and the demand for NMN supplements is growing, which has led to a limited supply and increased prices.
3. Quality control: High-quality NMN supplements should undergo rigorous testing and quality control measures to ensure purity and potency, which can also drive up costs.
To ensure that you are selecting the best possible NMN supplement, it is
crucial to ignore marketing language and carefully review the supplement
facts table. This will provide you with information on the ingredient
quality and any unwanted additives, allowing you to make an informed
decision and choose a high-quality NMN supplement.
However, taking all of these ingredients separately can be costly and impractical, as it would require taking numerous pills each day. That's why many top NMN supplements include a blend of other longevity ingredients to cover all bases.
There are numerous customer reviews of NMN supplements available online, but we have curated a selection of helpful ones below. Check out our recommended list of the best NMN and NAD booster supplements.
- Pure NMN Pro 100 Grams Bulk Powder.
- NMN Pro 300
- NMN Pro 1000
- Prohealth Longevity NMN Pro Complete (NMN, Trans-Resveratrol and TMG)
"Uthever’s research team is led by U.S. doctors from the
pharmaceutical giant GlaxoSmithKline. This NMN is tested both
in-house by Uthever and then batch-tested again by ProHealth to
verify authenticity and purity.
Painstaking attention to quality and purity has led to findings that ProHealth NMN remains intact and stable for up to two years. Pro 300 gets rave reviews, often beating popular products like Genex. Pay attention to price, however, as I’ve seen it fluctuate by nearly $50. I’ve also noticed that there isn’t a GMP-certified logo on the bottle itself. If you want a shelf-stable NMN that lasts, ProHealth Pro 300 is a top choice." - outliyr.com
Painstaking attention to quality and purity has led to findings that ProHealth NMN remains intact and stable for up to two years. Pro 300 gets rave reviews, often beating popular products like Genex. Pay attention to price, however, as I’ve seen it fluctuate by nearly $50. I’ve also noticed that there isn’t a GMP-certified logo on the bottle itself. If you want a shelf-stable NMN that lasts, ProHealth Pro 300 is a top choice." - outliyr.com
- One of the few NMN products from the ChromaDex NMN
Supplement Test Report (refer below) that passed the test
(contained at least 88% of the NMN label claim).
- ProHealth Uthever NMN is CLINICALLY PROVEN TO
BOOST NAD+ LEVELS IN HUMANS. In a peer reviewed, double blind placebo controlled clinical
study NAD+ decline was reversed by an average of 12 years. That's
38% more NAD+ in 60 days. Higher NAD+ levels are associated with
more energy, feeling younger, less genetic damage, heart health,
and SIRTUIN activation- longevity genes that are key for living
better longer. Also, study participants’ quality-of-life test
scores improved by 6.5%.
- ProHealth is the most trusted longevity supplement brand on the
market, celebrating 34 YEARS with a BBB A+ RATING. Other brands
may be cheaper, but do you trust that they actually contain any
NMN?
- PUREST, HIGHEST QUALITY, PHARMACEUTICAL GRADE NMN IN THE WORLD.
Every batch is 3rd party tested in a US lab to be at least 99.5%
pure, and independent lab tests prove that our NMN products
contain at least the number of grams of NMN per serving listed on
the label. All 3rd party lab Certificates of Analysis are publicly
posted. Our NMN is always manufactured in a FDA registered, GMP
certified facility in the USA.
- ProHealth Uthever NMN is proven safe for human consumption in a
clinical study. And our unique NMN capsules dissolve after passing
unharmed through the stomach so the potency is preserved when it
is delivered to the section of the intestine with the highest
absorption rates- maximizing bioavailability.
- SHELF STABLE FOR TWO YEARS, and at OVER 200 DEGREES. Lab tests
prove that ProHealth's Uthever NMN can be safely stored at ambient
room temperature for up to two years with no loss in quality or
potency. No refrigeration required.
|
| UTHEVER's CO-BRANDING PARTNERS |
2. TRU Niagen NAD+ Booster Supplement (Best NMN Alternative)
TRU Niagen NAD+ Supplement comes in 3 sizes:
- 30 count / Serving Size: 1 Capsule once a day - Servings Per Container: 30
- 90 count / Serving Size: 1 Capsule once a day - Servings Per Container: 90
- 120 count / Serving Size: 1 Capsule once a day - Servings Per Container: 120
Tru Niagen Reviews: 4.5 out of 5 - more than 4,000 global ratings
Amazon Best Sellers: #1 in Vitamin B3 (Niacin) Supplements.
- Technically, Nicotinamide Riboside is not the same molecule as
NMN but they are both NAD precursors and are categorised under
Vitamin B3 (Niacin) supplements by Amazon.com. Since, TruNiagen
is the #1 best seller, we have decided to feature them as part
of the best 10 list.
- ChromaDex markets TruNiagen, which is based on its branded
Niagen ingredient, which is a form of nicotinamide riboside
(NR), the form of nicotinamide that actively crosses into the
cell to participate in the NAD+ pathway (R).
- Reduces the cellular effects of aging by elevating NAD+, a
key coenzyme your body uses for healthy cellular metabolism.
- Nicotinamide Riboside for Energy, Metabolism, Vitality, Muscle
Health, Healthy Aging, Cellular Repair
- There are many cheaper alternative sources to buy NMN today, but
are you getting what you paid for? If the price for NMN is too
good to be true, it probably is not NMN.
Tru Niagen Review
While this is not a scientific review I have been taking Niagen
in one form or another non stop for several years. I have been
gradually increasing my doses with what I can only describe as a
profound effect. Without a doubt I feel younger than 46. I also
think I look younger than most people my age. I certainly don't
feel my age and have a ton of energy every single day. I also try
to eat plenty of vegetables with lots of non meat proteins along
with limited meat consumption. I am not a health nut but basically
try to stay away excess sugars and processed foods whenever I can.
I also do a hard bike ride once or twice a week. I think this also
helps the entire aging process some.
3. Nutricost Niacinamide
Amazon Best Sellers: #1 in Vitamin B3 (Niacin) Supplements.
Ratings: 4.6 out of 5 - more than 13,000 global ratings
Do not confused with Nutricost Niacin. Niacin is the form that may cause 'Niacin Flush'.
Niacinamide is the 'non-flush' form.
- Technically, Niacinamide is not the same molecule as NMN but
they are both NAD precursors and are categorised under Vitamin
B3 (Niacin) supplements by Amazon.com.
- Niacinamide is a popular form of Vitamin B3, but without the
often uncomfortable feeling known as "Niacin Flush". Vitamin B3
is most often found in meats like tuna and beef. However, in
order to get a similar amount of Vitamin B3, you would have to
eat large amounts of tuna and beef or other sources containing
Vitamin B3.
- Technically, Niacinamide is not the same molecule as NMN but
they are both NAD precursors and are categorised under Vitamin
B3 (Niacin) supplements by Amazon.com. Since, Niacinamide is the
#2 best seller under this category, we have decided to feature
them as part of the best 10 list.
- 240 Capsules of Niacinamide Per bottle / 1 Capsule per serving
- 500mg of Vitamin B3 (Niacinamide) Per Capsule
- No "Niacin Flush"
- Non-GMO, Gluten Free, Soy Free, and Made in a GMP Compliant,
FDA Registered Facility
Nutricost Niacinamide Review
After a recent news article about this being a favorite
supplement in Australia for sun damage protection, I asked my
dermatologist about it. She said it might help prevent me
getting as many 'barnacles' as she calls them. You know, those
nasty, old-age, sun-damage, crunchy brown or white patches all
over your body. (I have many). I'm still on my first bottle but
after about two weeks the most amazing thing happened. I
happened to scratch an area near one of my barnacles and it just
flaked off in my hand. Since then, many more have succumbed. Not
all; just some. But I'm happy. Even one less of those ugly bumps
is an improvement.
Niacinamide Review
Dr. Conlon has concluded, and Dr Mercola thoroughly agree with
her, that the best single NAD+ precursor is niacinamide (also
known as nicotinamide), not niacin, NR or NMN. It is now beyond
obvious to me why no one is promoting niacinamide. This is because
it costs less than one cent a day and as a result there is simply
no money to be made in promoting it. Ideally you buy niacinamide powder and use 1 to 1/2 of 1/64th of a teaspoon three times a day
(25-50 mg). - Mercola.com.
4. Thorne Research ResveraCel (Best Nicotinamide Riboside with Resveratrol and Quercetin Phytosome)
Amazon Best Sellers: #4 in Resveratrol Nutritional Supplements.
Ratings: 4.6 out of 5 - more than 500 global ratings
- Each capsule contains Nicotinamide Riboside (NR) ingredient, in addition to Resveratrol, Quercetin Phytosome, and Betaine.
- The ingredients in this product are complexed with Time-Sorb, a
time-release matrix.
- Supports healthy aging and helps regulate metabolism.
- Resveratrol and quercetin increase the activity of sirtuins.
- Betaine provides important methylation factors.
- Flavors, colors, preservatives, and sweeteners derived from
natural sources.
- No gluten, Genetically Modified Organisms (known as GMOs),
artificial preservatives, stearates, wheat, rye, barley, eggs, or
nuts. This product does not contain dairy, soy, corn, yeast, sugar,
or magnesium stearate.
- No unnecessary binders, coatings, disintegrants, fillers, or
lubricants (including magnesium stearate) that could impair
absorption.
- Adheres to the FDA’s current Good Manufacturing Practices (cGMPs)
and has the highest number of NSF Certified for Sport products which
tests for more than 200 banned substances for elite athletic
competitions.
Review - My husband and I are in our 60s and have been taking these capsules
for a few weeks. We both started with 2 capsules daily and
experienced an increase in energy and in focus. We also both had
trouble remaining asleep at night and had strange dreams. We have
decreased our consumption of the capsules to one per day and have
had a resolution to the sleep problems. We both continue to enjoy an
increase in energy and in focus. We have reordered this Thorne
product and are very satisfied with the results. It would be best to
start with one capsule per day and work up from there until you find
your own correct dosage.
Important safety note: Resveratrol is not suitable for
people undergoing blood-thinning medication.
5. aSquared Nutrition Nicotinamide with Resveratrol
Amazon Ratings: 4.5 out of 5 - more than 2,000 global ratings
Amazon Best Sellers: #8 in Resveratrol Nutritional Supplements.
aSquared Nutrition's maximum strength Nicotinamide supplement is
enhanced with Resveratrol to promote cellular health & repair,
normal NAD levels, longevity and anti-aging. Our unique formula
helps your cells metabolize & synthesize nutrients more
effectively to boost energy.
- 120 capsules per bottle
- 500mg of Nicotinamide per Capsule / 100mg of Resveratrol powder
per Capsule
- Contains 500mg of Non-Flush vitamin B3 per vegetable capsule,
and is enhanced with 100mg of Resveratrol powder (7% potency
yield) to promote cellular health & repair, normal NAD levels,
longevity and anti-aging.
- All Natural, Non-GMO, and Vegetarian
- Third Party Tested for Quality & Purity
- Supplement Pills to Support NAD, Anti Aging Skin Cell Health
& Energy
- Complex contains powerful antioxidants and anti-inflammatory
properties to combat poor aging.
- Made in USA
This product is probably about as close as you can get to the
niagen supplements, like Thorne ResveraCel, without actually
containing niagen or using the patented process. Nicotinamide is
a form of niacin easily processed by the body. And it contains
bonus resveratrol. I've only been taking these two weeks, but
I've found these supplements give me some mental boost/clarity
and physical energy. My skin seems more elastic. I have less
appetite (my usual tendency is to over eat) and sleep better.
I've lost a couple of pounds. One side effect I get is upset
stomach, but the seller/manufacturer claims this will go away
with time. Overall, while these supplements are no "miracle
cure," I think they are providing some benefit, and I will
continue to take them. I'll reevaluate once I've made it through
the first bottle.
TWO MONTH UPDATE: I still feel that I am benefiting from this
product. Stomach upset has diminished. I have less joint pain. I
have more energy and mental clarity. Better sleep. Skin feels
younger. No additional weight loss.
Important safety note: Resveratrol is not suitable
for people undergoing blood-thinning medication.
6. PerpetuaLife All in One Anti Aging Supplement
- 11 Anti-Aging compounds packed in one pill.
- Liposomal Nicotinamide Riboside 500mg, Resveratrol (trans-resveratrol) 400mg, L-Theanine 200mg, Fisetin 100mg, Astragalus 200mg, Curcumin (Tetrahydrocurcumin) 200mg, Collagen (Morikol Tripeptide CTP) 100mg, CoQ10 (Ubiquinol) 100mg, Crocin (Saffron) 100mg, Epigallocatechin gallate (EGCG) 100mg, Quercetin 500mg.
- Made, and distributed in the USA.
What Does NMN Supplement Do?
In numerous studies (2020), supplementation with NMN has increased NAD+
biosynthesis, suppressed age-related adipose tissue
inflammation, enhanced insulin secretion and insulin
action, improved mitochondrial function, improved neuronal
function in the brain, and more. Here, we look at the
science behind NMN, its stability, possible
pharmacokinetics, transport, function, and ability to
induce biosynthesis of NAD+. Supplementing NMN may be an
effective nutraceutical anti-aging intervention, with
beneficial effects on a wide array of physiological
functions.
This has precipitated dozens of studies since that are focused on investigating NMN supplementation to treat cardiovascular disease, diabetes, obesity, life extension, cancer, Alzheimer’s disease, Parkinson’s disease, and many more.
Benefits of NMN supplements
There is preliminary evidence to suggest that NMN supplements may have the following potential benefits:1. Anti-aging effects: Some studies have suggested that NMN may help improve cellular health, reduce oxidative stress, and potentially have anti-aging effects.
2. Improved insulin sensitivity: NMN has been shown to improve insulin sensitivity and glucose metabolism.
3. Improved cardiovascular health: NMN has been shown to improve cardiovascular function and reduce oxidative stress in the heart, which may help support overall heart health.
4. Enhanced exercise performance: Some studies have suggested that NMN supplementation may help improve exercise performance and recovery in animals.
Chromadex NMN Supplement Test Report: 64% of NMN Supplements Fail Tests
ChromaDex NMN Report (Oct 2021): Supplement manufacturer ChromaDex alleges that
testing has revealed that more than half of NMN anti aging
supplements being sold on Amazon contained almost none of the
bioactive molecule.
ChromaDex markets TruNiagen, which is based on its branded Niagen
ingredient, which is a form of nicotinamide riboside (NR), the
form of nicotinamide that actively crosses into the cell to
participate in the NAD+ pathway. Boosting this pathway, and thus
maintaining cellular function at a lively, youthful level, has
become a prominent theme in recent anti aging research.
|
| Credit: ChromaDex |
* The same distributor (SerumLab S&C International LLC) was
listed on the product packaging from 10 of the 22 product
brands.
Some researchers have argued that a transporter exists for NMN
too, which is something that ChromaDex disputes. It claims that NMN must first be converted into NR in the blood
before it can be used by the cells.
In the several years since the NMN transporter discovery was
asserted, the NAD+ anti aging field has become crowded with NMN
based supplements all seeking a piece of the pie created by
ChromaDex and its competitor and one time customer Elysium. (The
two companies have been locked in various patent infringement and
breach of contract suits for several years.)
Last fall, ChromaDex obtained 22 samples of NMN products being
sold on Amazon. Of these, 14 claimed to contain 500 mg of NMN. A
further two products claimed 300 mg on the label; five claimed 250
mg and one product claimed 125 mg.
Only one of the 500 mg products came close to meeting label claim.
It had 456 mg of NMN. All of the other 13 products in the 500 mg
group either came in at below reporting limit (BRL, defined as
less than 1% of the stated amount) or, in the case of 3 products,
no NMN was detected at all.
Almost all of the rest of the products performed better, having at
least 88% of the label claim. A lone 250 mg product was identified
as BRL.
In summary, ChromaDex said that 64% of the products tested
contained less than 1% of the stated amount of the active
ingredient, which should give consumers pause, the company said.
"While this is a limited snapshot of the vast NMN finished
product landscape, it does provide a glimpse into the high
variability of product quality that is available... According to
this study, the majority of the products one might purchase
online contain such a small amount of NMN that there would be no
clinical benefits achieved from the dose. Another concern with
these adulterated products is that the actual contents are not
known and could pose a risk to the user," the company said in a statement.
David Sinclair Supplements List
Keep in mind that to date, Dr. David Sinclair has made a point to not promote or endorse any supplement products. We compiled this list from interviews and books in which Professor David Sinclair mentions supplements he takes.We don’t know if he still takes these supplements, or whether he takes additional supplements that are not included on this list.
For example, in his book Lifespan, he mentions on page 304 that he takes NMN and resveratrol every morning, often mixed in his yogurt.
Here is the summary list:
- Nicotinamide Mononucleotide (NMN), 1g per day, in the morning
- Quercetin and fisetin, 500 mg each, once per day, in the morning
- Resveratrol, 1g per day, in the morning
- Vitamin D3 and K2
- Spermidine, 1 mg per day, in the morning
- Metformin (prescription drug) 1 gram per day: 500 mg in the morning and 500 mg in the evening
- Statin (prescription drug) – taken since his early 20s due to family history of cardiovascular disease
- Low-dose aspirin – 83 mg per day
- Alpha lipoic Acid
- Coenzyme Q10
He is also a co-founder of a pharmaceutical company called
MetroBiotech which has begun clinical trials with a special,
crystalline form of NMN called MIB-626.
But this will presumably be for sale as a drug to treat specific medical conditions, if the studies show positive outcomes.
But this will presumably be for sale as a drug to treat specific medical conditions, if the studies show positive outcomes.
NR vs NMN Molecule
Pitting NR vs NMN against each other is, for now, somewhat of a moot point
because the two molecules have never been studied side by side in
humans. The biggest, and most obvious, difference between NMN and NR
is size. NMN is simply larger than NR, meaning it often needs to be
broken down to fit into the cell. NR (Nicotinamide Riboside), when
compared to other NAD+ precursors (like nicotinic acid or
nicotinamide) reigns supreme in efficiency.
But give NMN a new door, one it can fit through, and it’s a whole
new game. This is where cellular transporters come into play.
Transporters are proteins that are doors on the cell; they allow
molecules to enter the cell without needing to chemically
transform.
Research from Shin-ichiro Imai, M.D., Ph.D., a professor of
developmental biology at Washington University in St. Louis,
identified a transporter that allows NMN to get into the cell
without converting to NR. The catch? The transporter is only on
cells located in the gut of mice and only works in the presence of
sodium ions. NR, however, has been shown to enter cells in the
liver, muscle, and brain tissue of mouse models. To date there is
not yet evidence that these mouse studies can be extrapolated to
humans. But again, the two have never been matched up against each
other in a way that can truly identify one as superior to the
other.
Stability and storage of NMN and NR
A stability analysis demonstrates NR is stable (does not undergo degradation) for up to six hours at room temperature and seven days at two to eight degrees Celsius. Regarding stability of NMN and NR, David Sinclair, PhD, A.O. of Harvard University says, “Make sure your NR and NMN is kept in the cold. If it’s just on the shelf and it’s not in a stabilized form, then it will degrade to nicotinamide, which is something you don’t want to take high doses of because we’ve shown in my lab many years ago that nicotinamide will inhibit the sirtuins, and PARP as well, and interfere with DNA repair.”What Foods Contain NMN?
The aim of taking NMN supplements is to boost NAD levels. So you
need to look out for foods that are rich in NAD precursors, not just
NMN. As lots of different molecules can be converted to NMN, and
then NAD.
• Vitamin B3 rich foods: Foods that are high in niacin (vitamin B3) can help increase NAD+ levels in the body. Good sources of niacin include yeast, beef liver, poultry, fish, and whole grains.
• Leafy greens: Leafy greens, such as spinach and kale, are rich in folate, which can help increase NAD+ levels in the body.
It is important to note that foods which are high in NAD precursors do not necessarily increase NAD or NMN levels. Despite having an abundance of NAD precursors in your diet, your cells can use these nutrients for other processes and may not use them to produce NMN and then NAD.
On the other hand, NMN supplements push your cells to produce more NAD which has been shown in several animal and a few human studies.
NMN is available in vegetables (broccoli and cabbage), avocado,
mushrooms, meat, and shrimp but trying to obtain sufficient
through diet alone would be problematic.
Study dosages have been about 50mg - 250mg and suggested that a
150 pound (68kg) human would require about 560mg per day. The
difficulty is that you would have to eat about 100 pounds of
edamame, 1,800 pounds of broccoli, or similarly impossible amounts
of cucumber, cabbage, avocado, tomato, mushrooms, raw beef, or
shrimp.
FAQs
What makes a good NMN supplement?With so many different supplements on the market claiming to be the best, it's hard to know which one is worth investing in. Realistically, there are only a few things that really matter:
1. Purity
The best NMN supplements use 98% purity NMN. It's as simple as that, always look for this level and nothing less should make the cut. After all, it's obvious that we all want a supplement that contains as much of the active ingredient as possible.
2. Dosing
There is no official recommended dose of NMN. It's a relatively new supplement and most brands contain between 250mg - 750mg per serving which is based on the limited amount of research on this ingredient. David Sinclair openly says that he takes 1000mg of NMN a day which is a relatively high dose.
A recent study published in February 2023 tested daily NMN at doses of 300mg, 600mg, and 900mg over a 60-day period in healthy adults of 40-65 years old.
There were no side effects reported and they found that NAD levels increased in all of these doses. It's important to highlight this was a small study of only 80 individuals and the study only ran for 60 days so it's not clear what the long-term outcomes will be. There are a lot of unknowns when it comes to NMN dosing and you need to decide what feels right for you. (1 )
3. Quality
Quality is one of the more challenging things to determine when it comes to choosing an NMN supplement. Taking a close look at the supplement facts table is a good place to start. The best NMN supplements aim to keep the formula as clean as possible. They avoid ingredients like magnesium stearate, artificial fillers and ensure that the capsules are sustainably vegan. Look out for "other ingredients" on the product label and you'll quickly realize if you're looking at a high-quality NMN supplement or not.
How long does it take for NMN to start working?
There are a handful of studies that show taking NMN can boost NAD levels within a few weeks. A study we mentioned earlier saw a measurable rise in blood NAD levels after just 30 days.
In reality, NMN supplements are likely to boost NAD levels sooner than this.
But the time it takes for biological benefits to be seen is not yet known in humans. It's currently under investigation and more information will come out in the next few years.
Some people report having more energy and better skin, but most people won't actually 'feel' anything. It's more so that the benefits are occurring at a cellular level which you won't necessarily be able to consciously notice.
Is NMN just vitamin B3?
The answer to this question is now obvious from the above. NMN is vitamin B3 + sugar + phosphate. So it's not just vitamin B3. It's two steps further along in the chain.
At this stage, most people think that they'll just take Vitamin B3 and that will eventually form NMN. But the issue is that a lot of energy is required to go from vitamin B3 to NMN and our cells won't naturally go down this route.
What are the side effects of taking NMN supplements?
As with all things NMN related, there isn't much solid information on NMN side effects. There are only a handful of studies using NMN in humans. Side effects are seldom reported and doses up to 1000mg are generally well-tolerated.
For example, one study gave 250 mg/day of NMN for 10 weeks to 25 prediabetic women who were overweight or obese without any adverse effects. (2)
But this does not mean that you won't experience any side effects. As with any supplement, the risk of experiencing a negative reaction is always possible. So always discuss this with your physician, especially if you have any other medical conditions and taking any medicines.
Is NMN safe to take long term?
It's really important to understand that there are no long term studies into NMN supplementation. Most studies run for a maximum of a few months. So there's a big question mark over the safety profile of long term NMN usage.
Although no red flags have been raised with respect to NMN just yet, it's very early days. It will be years before we know if NMN is safe to take long term and which dose is best.
So you have to decide for yourself whether taking NMN supplements is worth it.
At what age should you take NMN supplements?
There's no hard and fast rule for when you should start taking NMN supplements.
Hardcore advocates of NMN will say the sooner the better!
NAD levels decline at different rates depending on what organ you're looking at. But it's generally believed that NAD levels drop by about 50% every 20 years.
So whether you're in your 30s or 70s, the question of when you should start taking NMN supplements is not relevant. If you've done your research and want to take
NMN supplements, the best time to start is arguably now.
Can NMN reverse wrinkles?
NMN supplements are not the magic elixir for youth. It's effects are largely seen on a cellular level and the majority of people won't visibly see any changes in their exterior appearance.
With that said, some people have reported smoother skin, fewer wrinkles and reduction in grey hairs. But it's not been properly proven in research studies and it could be a placebo effect.
It is also important to keep in mind that wrinkles are a natural part of the aging process, and are caused by a variety of factors including genetics, exposure to the sun and other environmental factors, and lifestyle choices such as smoking and poor diet.
It's best to think of NMN supplements as a longevity aid that works on a cellular level. Rather than taking them with the aim of having a more youthful appearance.
How can I increase my NMN naturally?
In your quest for the best NMN supplement, you may be thinking you also want to try and increase your levels naturally.
In reality, what you're trying to increase is your NAD levels. And NMN supplements are only one of many ways in which you can boost your NAD levels.
1. High intensity interval training
All exercise is good. But studies have shown that high intensity interval training (HIIT) is particularly good. It's not suitable for everyone because the intensity can have negative health implications for people with underlying conditions (for example heart arrhythmias). (3 )
HIIT can be achieved with many different types of exercise. For example:
- short sprint bursts followed by a light jog
- Spin classes (i.e short bursts of vigorous cycling followed by lower intensity cycling)
- HIIT classes (which involve various bodyweight exercises)
But even something like doing jumping jacks intensely or high knee raises at home achieves a similar effect.
The theory is that the bursts of high activity mimic "threat" or "danger" which would have been a frequent occurrence as humans evolved on the savannahs of Africa hundreds of thousands of years ago. And this activates certain longevity genes.
But there's a sweet spot because if it's pushed too far, HIIT can be damaging. So it's best to start after a discussion with your physician and a trainer to assess your level.
2. Fasting
Going for prolonged periods without any calories has been shown to activate genes that extend longevity at a cellular level. When food is scarce, the body is tricked into thinking that "hard times are coming". In other words, the cells start activating genes that increase NAD levels in preparation for the perceived hardship. (4 )
A common entry-level regimen is the 18:6 Intermittent fasting. Essentially, only eating in a 6-hour window and having no calories at all for 18 hours. Some people just opt to eat once a day and others fast for several days at a time.
The studies show that the more aggressive regimens have the most health benefits. But of course, it's extremely difficult to maintain and definitely not suitable for the majority of people. But the entry-level fasting regimens are not too challenging. As always, speak to your doctor first.
3. Heat and cold shock
You've probably guessed the theme by now. Your cells respond to stress by activating protective genes. So the same applies to heat and cold shock. For example, using ice baths.
Obviously, there's a fine line between experiencing health benefits and harm. Pushing any of this too far can have serious health consequences. So if you're thinking of trying any of the above, you really must speak to a trained professional to get advice on how to start.
Is NMN hard on the liver?
There is currently no evidence to suggest that NMN is harmful to the liver. In fact, some studies have suggested that NMN may have a positive effect on liver health, as it has been shown to improve insulin sensitivity and reduce oxidative stress in liver cells.
However, it is important to keep in mind that NMN is a relatively new molecule and more research is needed to fully understand its effects on the body, including its impact on the liver.
Which is better: NMN or resveratrol?
It's hard to compare NMN and Resveratrol as they are completely different compounds with unique properties. Professor David Sinclair is an advocate of both and takes them daily.
Resveratrol is a natural compound formed in various foods such as grapes, red wine, and some berries. It's an antioxidant and anti-inflammatory compound in its own right. It has also been shown to increase NAD levels indirectly by activating certain pathways which are different to how NMN works.
In summary, NMN and resveratrol work differently and you can't directly compare them. That's why the best resveratrol supplements often combine these powerful ingredients together.
Why are NMN supplements expensive?
NMN supplements can be expensive for several reasons:
1. Production costs: NMN is a relatively new molecule and the production process can be complex and time-consuming, which pushed the price up.
2. Limited supply: NMN is not found in large quantities in natural food sources, and the demand for NMN supplements is growing, which has led to a limited supply and increased prices.
3. Quality control: High-quality NMN supplements should undergo rigorous testing and quality control measures to ensure purity and potency, which can also drive up costs.
Best NMN supplements - Final words
As human trials continue to demonstrate positive health benefits, NMN supplements are likely to become increasingly popular in the coming years.
For more details on other anti aging supplements, check out
"10 Best Anti Aging Supplements 2024 - Evidence Based". This article is part of the Anti Aging series.
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