10 Best NMN Supplements To Buy In 2024

NMN is one of the most popular supplements in the anti aging community. The global Nicotinamide Mononucleotide (NMN) market was valued at US$ 98.5 million in 2019 and it is expected to reach US$ 296.5 million (R) by the end of 2026, growing at a CAGR (Compound Annual Growth Rate) of 7.3% during 2021-2026.

NMN is the precursor to NAD, which our cells use to power metabolic activity. In other words, NAD is essential for our cells to generate energy and thrive.

By middle age, our NAD levels have plummeted to half that of our youth. And this decline has been linked to various age-related diseases. The hope is that NMN, being the direct precursor to NAD, can boost levels and extend longevity.

What actually is NMN?

NMN is short for Nicotinamide mononucleotide and it's the precursor to NAD (Nicotinamide adenine dinucleotide). In fact, two NMN molecules combined together make NAD.

But NMN is actually one of many intermediary molecules before the formation of NAD.

In fact, it all starts with vitamin B3, also called Niacin or Nicotinamide.

Our cells combine Vitamin B3 with sugar. This compound is also called Nicotinamide Riboside (NR)

The next step is the addition of phosphate to NR. This new compound is called NMN as we know it. In other words, NMN = vitamin B3 + sugar + phosphate

Finally, two NMNs are combined together to form NAD.

So our cells naturally manufacture NMN as part of the process of making NAD.

In summary, NMN is an intermediary molecule in the pathway to producing NAD. Our cells naturally produce NMN from vitamin B3. NAD levels rise by taking NMN supplements because it's the direct precursor and circumvents the need for the initial two steps in the pathway to NAD production.

10 Best NMN Supplements 2024

Although there are many NMN supplement customer reviews on many online sites, we have sifted and curated some of the most helpful ones below. Not all NMN supplements are created equal. Check out below our 10 best NMN supplements league.

Note: Amazon's decision to stop selling NMN supplements in the U.S. is tied to a determination in 2022 by the U.S. Food and Drug Administration. The U.S. Food and Drug Administration in 2022 concluded that NMN is excluded from dietary supplement products because it is the subject of substantial clinical investigations that have been been instituted and made public.  

Therefore, we have shortlisted the 10 best NMN alternatives.

1. Nutricost Niacinamide (Best Affordable NMN Alternative)



Amazon Best Sellers: #1 in Vitamin B3 (Niacin) Supplements.

Ratings: 4.6 out of 5 - more than 16,000 global ratings

Do not confused with Nutricost Niacin. Niacin is the form that may cause 'Niacin Flush'. Niacinamide is the 'non-flush' form.

- Technically, Niacinamide is not the same molecule as NMN but they are both NAD precursors and are categorised under Vitamin B3 (Niacin) supplements by Amazon.com.
- Niacinamide is a popular form of Vitamin B3, but without the often uncomfortable feeling known as "Niacin Flush". Vitamin B3 is most often found in meats like tuna and beef. However, in order to get a similar amount of Vitamin B3, you would have to eat large amounts of tuna and beef or other sources containing Vitamin B3.
- Technically, Niacinamide is not the same molecule as NMN but they are both NAD precursors and are categorised under Vitamin B3 (Niacin) supplements by Amazon.com. Since, Niacinamide is the #2 best seller under this category, we have decided to feature them as part of the best 10 list.
- 240 Capsules of Niacinamide Per bottle / 1 Capsule per serving
- 500mg of Vitamin B3 (Niacinamide) Per Capsule
- No "Niacin Flush"
- Non-GMO, Gluten Free, Soy Free, and Made in a GMP Compliant, FDA Registered Facility

Nutricost Niacinamide Review
After a recent news article about this being a favorite supplement in Australia for sun damage protection, I asked my dermatologist about it. She said it might help prevent me getting as many 'barnacles' as she calls them. You know, those nasty, old-age, sun-damage, crunchy brown or white patches all over your body. (I have many). I'm still on my first bottle but after about two weeks the most amazing thing happened. I happened to scratch an area near one of my barnacles and it just flaked off in my hand. Since then, many more have succumbed. Not all; just some. But I'm happy. Even one less of those ugly bumps is an improvement.

Niacinamide Review
Dr. Conlon has concluded, and Dr Mercola thoroughly agree with her, that the best single NAD+ precursor is niacinamide (also known as nicotinamide), not niacin, NR or NMN. It is now beyond obvious to me why no one is promoting niacinamide. This is because it costs less than one cent a day and as a result there is simply no money to be made in promoting it. Ideally you buy niacinamide powder and use 1 to 1/2 of 1/64th of a teaspoon three times a day (25-50 mg). - Mercola.com.

2. TRU Niagen NAD+ Booster Supplement (NMN Alternative)



TRU Niagen NAD+ Supplement comes in 3 sizes:

Amazon Best Sellers: #2 in Vitamin B3 (Niacin) Supplements.

- Technically, Nicotinamide Riboside is not the same molecule as NMN but they are both NAD precursors and are categorised under Vitamin B3 (Niacin) supplements by Amazon.com. Since, TruNiagen is the #1 best seller, we have decided to feature them as part of the best 10 list.
- ChromaDex markets TruNiagen, which is based on its branded Niagen ingredient, which is a form of nicotinamide riboside (NR), the form of nicotinamide that actively crosses into the cell to participate in the NAD+ pathway (R). 
- Reduces the cellular effects of aging by elevating NAD+, a key coenzyme your body uses for healthy cellular metabolism.
- Nicotinamide Riboside for Energy, Metabolism, Vitality, Muscle Health, Healthy Aging, Cellular Repair 
- Unlike NMN, the key ingredient Niagen was successfully notified two times as an NDI (New Dietary Ingredient) and reviewed as GRAS (Generally Recognized As Safe) under the United States notification programs.
- There are many cheaper alternative sources to buy NMN today, but are you getting what you paid for? If the price for NMN is too good to be true, it probably is not NMN.
 
Tru Niagen Review
While this is not a scientific review I have been taking Niagen in one form or another non stop for several years. I have been gradually increasing my doses with what I can only describe as a profound effect. Without a doubt I feel younger than 46. I also think I look younger than most people my age. I certainly don't feel my age and have a ton of energy every single day. I also try to eat plenty of vegetables with lots of non meat proteins along with limited meat consumption. I am not a health nut but basically try to stay away excess sugars and processed foods whenever I can. I also do a hard bike ride once or twice a week. I think this also helps the entire aging process some.

Tru Niagen vs Elysium Basis

3. Thorne Research ResveraCel (Best Nicotinamide Riboside with Resveratrol and Quercetin Phytosome)


Amazon Best Sellers: #4 in Resveratrol Nutritional Supplements.

Ratings: 4.6 out of 5 - more than 600 global ratings

Trusted by 12 U.S. National teams and many professional sports teams, Thorne research provides safe, effective products free of contamination. If you can’t (or don’t want to) risk accidentally consuming banned substances, Thorne’s got you covered.

- Each capsule contains Nicotinamide Riboside (NR) ingredient, in addition to Resveratrol, Quercetin Phytosome, and Betaine. 
- The ingredients in this product are complexed with Time-Sorb, a time-release matrix.
- Supports healthy aging and helps regulate metabolism.
- Resveratrol and quercetin increase the activity of sirtuins.
- Betaine provides important methylation factors.
- Flavors, colors, preservatives, and sweeteners derived from natural sources. 
- No gluten, Genetically Modified Organisms (known as GMOs), artificial preservatives, stearates, wheat, rye, barley, eggs, or nuts. This product does not contain dairy, soy, corn, yeast, sugar, or magnesium stearate.
- No unnecessary binders, coatings, disintegrants, fillers, or lubricants (including magnesium stearate) that could impair absorption.
- Adheres to the FDA’s current Good Manufacturing Practices (cGMPs) and has the highest number of NSF Certified for Sport products which tests for more than 200 banned substances for elite athletic competitions.

Review - My husband and I are in our 60s and have been taking these capsules for a few weeks. We both started with 2 capsules daily and experienced an increase in energy and in focus. We also both had trouble remaining asleep at night and had strange dreams. We have decreased our consumption of the capsules to one per day and have had a resolution to the sleep problems. We both continue to enjoy an increase in energy and in focus. We have reordered this Thorne product and are very satisfied with the results. It would be best to start with one capsule per day and work up from there until you find your own correct dosage.

Important safety note: Resveratrol is not suitable for people undergoing blood-thinning medication.

4. Liposomal Nicotinamide Riboside, Resveratrol & Quercetin Phytosome by Reus Research


Ratings: 4.7 out of 5 - more than 70 global ratings 

About this item
  • INCREASE NAD BY 63%: Fight aging with Liposomal Nicotinamide Riboside - the direct sub to NMN supplements. It helps your body absorb and utilize NAD precursor more efficiently, producing wonderfeel results.
  • MADE & TESTED IN THE USA: Our NR supplement is made and third-party tested in the USA to ensure its purity and effectiveness. Certificate available upon request. Get back to feeling your best with NAD+ supplement booster.
  • INCREASE ABSORPTION BY 71%: maximize bioavailability with our Liposomal Nicotinamide Riboside encapsulation technology. Unleash the full potential of this supplement and experience 50% more effectiveness compared to other delivery methods.
  • FEEL YOUTHFUL AGAIN: With daily dose of our Liposomal Nicotinamide Riboside capsules, you'll get a unique blend that supports healthy aging, energy production, focus and longevity.
Important safety note: Resveratrol is not suitable for people undergoing blood-thinning medication.

5. ELYSIUM Basis NAD Supplement - Nicotinamide Riboside (NR) Supplement 250mg with Pterostilbene




Technically, Nicotinamide Riboside is not the same molecule as NMN but they are both NAD precursors and are categorised under Vitamin B3 (Niacin) supplements by Amazon.com. 

Elysium Health is a startup cofounded by Sinclair's former mentor, MIT biologist Leonard Guarente. Elysium is taking no chances when it comes to scientific credibility. Its website lists a dream team of advising scientists, including five Nobel laureates and other big names such as the Mayo Clinic's Jim Kirkland, a leader in geroscience, and biotech pioneer Lee Hood.

Compared to other usual sources of NR, the price of Basis is relatively higher. However, those other products lack pterostilbene, and ELYSIUM is a trusted brand.

Ratings: 4.2 out of 5 - more than 70 global ratings 

About this item
  • Want healthy aging? We’re the experts. Leonard Guarente, Elysium Health co-founder, has been studying aging for three decades. Our flagship product, Basis, is formulated to raise NAD+ by 40%, combat aging at the deepest level—your cells, and has sold over 3.5 million bottles. TIME magazine has called Basis “the supplements experts take.” All our products contain rigorously studied ingredients, and we partner with major research institutions like Oxford and Yale.
  • Why should you take NAD? At a recent conference, 80% of doctors were taking an NAD+ supplement. What do they know that we don’t? In scientific research, NAD+ levels correlate with health status—it helps protect your DNA from stressors, boost cellular energy, and support healthy muscle function, and we have less of it as we age. Luckily, there’s a way to safely and sustainably raise your NAD+: Basis has been proven to increase levels by 40% in a double-blind, placebo-controlled clinical trial.
  • Basis contains two powerful components: Proprietary nicotinamide riboside (NR-E), the raw material your body uses to make NAD+, and pterostilbene (PT), a plant polyphenol that protects against stress. From day 1, these ingredients support cellular energy, mitochondrial function, and protect cells from everyday stressors.
  • Be sure of what’s in your supplement: We set the industry standard. We publicly publish the quality and purity results of third-party testing on every lot of Basis so you know exactly what you’re putting in your body. Our supplements are NSF Certified for Sport. We partner with major institutions like Oxford and Yale, and our company decisions are guided by the expertise of our Scientific Advisory Board, which includes internationally recognized experts and 8 Nobel laureates.
  • Need more proof that Basis is the science-backed choice, and the superior NAD+ product on the market? TIME magazine called Basis “the supplement experts take,” W Magazine has said “This is the supplement sitting on the nightstands of every cerebral beauty junkie,” and Good Housekeeping has awarded us their Innovation Emblem to recognize trailblazing initiatives in health and wellness. We’ve been featured in many other publications and are the choice for doctors, athletes, and celebrities alike.

6. Codeage Liposomal NMN + Resveratrol + Quercetin + TMG Supplement


Buy on iHerb (over 800 reviews)

Click to Enlarge

About this item
  • Liposomal delivery matrix: NAD precursor blend offering NMN nicotinamide mononucleotide + resveratrol, betaine (TMG), riboflavin, vitamin B12, and quercetin all-in-one through a liposomal phospholipid complex.
  • NAD Supplement Precursor & Betaine: This NAD precursor athletic fitness formulation delivers 85 mg of betaine anhydrous in each serving. Also called trimethyglycine (TMG), betaine usually consists of an amino acid derived from plants and sugar beets. NAD has been researched for its role on stem cells, telomere, and cellular energy. The combination of trimethylglycine and NMN ensures you get the energy increase from NAD while the improved distribution with TMG. 
  • Riboflavin & Vitamin B12 with Quercetin: Codeage Liposomal NMN formula also combines two of the vitamin B complex essential vitamins as well as quercetin. This formula provides Vitamin B2 as riboflavin-5-phosphate and vitamin B12 as methylcobalamine. These essential vitamins to support the metabolism have been blended with quercetin dihydrate from Japanese sophora flowers.
  • Manufactured in the USA: Codeage NMN & resveratrol vitality blend is non-GMO and manufactured in the USA in a cGMP certified facility. This liposomal nicotinamide with riboflavin supplement doesn't contain any fillers, hormones, or artificial ingredients. Third-party tested.
  • Liposomal delivery matrix: NAD precursor blend offering NMN nicotinamide mononucleotide + resveratrol, betaine, riboflavin, vitamin B12, and quercetin all-in-one through a liposomal phospholipid complex.
  • Suggested use: Take 3 capsules daily with 8 ounces of water or your favorite beverage. May be taken with or without food.
  • iHerb Best Seller Product Rank: #2 in Nicotinamide Mononucleotide (NMN) category;
    #2 in NAD+ category.
  • Over 800 customer reviews, most of them 5-stars on iHerb.com.
Important safety note: Resveratrol is not suitable for people undergoing blood-thinning medication.

Related evidence: Published in Pharmacology Research and Perspectives (2022), Jiang and colleagues from Macau University of Science and Technology in China demonstrated that combining NMN with resveratrol increases NAD+ levels in heart and skeletal muscle of mice significantly more than NMN alone.

7. ProHealth Longevity NMN Pro 500


Buy on iHerb (capsules)

Also available as: 
ProHealth Longevity NMN Pro Review:
"Uthever’s research team is led by U.S. doctors from the pharmaceutical giant GlaxoSmithKline. This NMN is tested both in-house by Uthever and then batch-tested again by ProHealth to verify authenticity and purity.
Painstaking attention to quality and purity has led to findings that ProHealth NMN remains intact and stable for up to two years. Pro 300 gets rave reviews, often beating popular products like Genex. Pay attention to price, however, as I’ve seen it fluctuate by nearly $50. I’ve also noticed that there isn’t a GMP-certified logo on the bottle itself. If you want a shelf-stable NMN that lasts, ProHealth Pro 300 is a top choice." - 
outliyr.com

- One of the few NMN products from the ChromaDex NMN Supplement Test Report (refer below) that passed the test (contained at least 88% of the NMN label claim).
- ProHealth Uthever NMN is CLINICALLY PROVEN TO BOOST NAD+ LEVELS IN HUMANS. In a peer reviewed, double blind placebo controlled clinical study with 66 participants, NAD+ decline was reversed by an average of 12 years. That's 38% more NAD+ in 60 days. Higher NAD+ levels are associated with more energy, feeling younger, less genetic damage, heart health, and SIRTUIN activation- longevity genes that are key for living better longer. Also, study participants’ quality-of-life test scores improved by 6.5%.
- ProHealth is the most trusted longevity supplement brand on the market, celebrating 34 YEARS with a BBB A+ RATING. Other brands may be cheaper, but do you trust that they actually contain any NMN?
- PUREST, HIGHEST QUALITY, PHARMACEUTICAL GRADE NMN IN THE WORLD. Every batch is 3rd party tested in a US lab to be at least 99.5% pure, and independent lab tests prove that our NMN products contain at least the number of grams of NMN per serving listed on the label. All 3rd party lab Certificates of Analysis are publicly posted. Our NMN is always manufactured in a FDA registered, GMP certified facility in the USA.
- ProHealth Uthever NMN is proven safe for human consumption in a clinical study. And our unique NMN capsules dissolve after passing unharmed through the stomach so the potency is preserved when it is delivered to the section of the intestine with the highest absorption rates- maximizing bioavailability.
- SHELF STABLE FOR TWO YEARS, and at OVER 200 DEGREES. Lab tests prove that ProHealth's Uthever NMN can be safely stored at ambient room temperature for up to two years with no loss in quality or potency. No refrigeration required.

UTHEVER's CO-BRANDING PARTNERS
 

8. Wonderfeel NMN

This is not your average NAD supplement. Wonderfeel® Youngr™ NMN provides a unique solution to aging; this NAD-boosting, patented formula has been developed by Harvard Med-trained entrepreneur and inventor Professor Andrew Salzman MD, who has worked in biomedical drug discovery for more than three decades.

With a dose backed by a human clinical trial based on cutting-edge science, Youngr aims to change the way you age. One of the most comprehensive NMN clinical trial to date on human subjects, with 80 participants ranging between the ages of 40 and 65, and an eye to determining dosing efficacy. The study is now peer-reviewed. The study confirmed that NMN effectively raises NAD levels in the blood, and health scores for participants taking NMN improved significantly over the course of the trial. In addition to substantiating the role of NMN in human health, the study also highlights the importance of dosing for efficacy.

Youngr™ NMN is a patented solution to aging. Formulated with emergent antioxidants and sirtuin activation, it uses a multi-targeted approach to defend and slow down biological aging at the cellular level.

Ingredients

60 Capsules per Bottle. Each capsule contains:
  • 450 mg Nicotinamide Mononucleotide
  • 2 mg Ergothioneine
  • 50 mg Trans Resveratrol
  • 40 mg Olea25® (25% hydroxytyrosol)
  • 10 mcg Vitamin D3 (Cholecalciferol)
Does not contain soy, gluten, dairy or fish. Non-GMO, vegan friendly, does not contain preservatives. Rice hull powder added for stabilization. Capsule shells are made from vegetable cellulose and are 100% vegan.

9. Life Extension NAD+ Cell Regenerator and Resveratrol Elite

  • NAD+ Cell Regenerator™ and Resveratrol Elite™ is Life Extension's Best in Class formula for energy support. It combines 300 mg of NIAGEN® nicotinamide riboside with an ultra-bioavailable trans-resveratrol (as well as bioavailability-enhanced forms of the phytonutrients quercetin and fisetin) to fight general fatigue and promote longevity with every dose.
  • NIAGEN® nicotinamide riboside increases your levels of NAD+, an enzyme critical to healthy cellular energy production. Resveratrol promotes a variety of health and longevity mechanisms; quercetin supports heart and immune health; and fisetin encourages your body to clear senescent cells. This formula combines highly bioavailable forms of all four of these nutrients, creating an unrivaled supplement for energy, vitality and defense against cellular aging.
  • iHerb Best Seller Product Rank: #1 in Fisetin category; #2 in Nicotinamide Riboside category.
  • Over 1,000 customer reviews, most of them 5-stars on iHerb.com.


10. Peak Performance NMN + Resveratrol

peak performance nmn resveratrol

Update: Not available on Amazon

Not all NMN supplements are created equal! Many supplements come with just NMN, which by itself is less effective to produce higher levels of NAD which the body needs to prevent cellular degeneration as we age. Peak Performance combines NMN with Resveratrol. Resveratrol works synergistically with NMN as it acts as an accelerator to produce better results in DNA repair.
- Published in Pharmacology Research and Perspectives (2022), Jiang and colleagues from Macau University of Science and Technology in China demonstrated that combining NMN with resveratrol increases NAD+ levels in heart and skeletal muscle of mice significantly more than NMN alone.
- Anti Aging = NMN + Resveratrol! Our cells use NAD+ to produce energy and to activate proteins that repair damaged DNA. Scientists believe that the decline of NAD+ as we age results in many health-related problems. To sustain healthy levels of NAD+ we can supplement this with its precursor, nicotinamide mononucleotide (NMN) . When combined with Resveratrol this supplement becomes even more powerful. Great for cellular + DNA repair, muscle endurance and strength, vascular health and blood flow.
- What's in your supplement? - Many supplements on the market use standard formulas that may contain cheap fillers and sometimes questionable ingredients. All of our ingredients are carefully chosen and 3rd party tested for purity.
- Vegan & Allergy Free - Free Of Soy, Milk, Egg, Shellfish, Corn, Wheat & Peanuts. Contains NO Gluten or Preservatives. Manufactured Under The Highest Quality GMP Regulations and USA Standards.

What Does NMN Supplement Do?

In numerous studies (2020), supplementation with NMN has increased NAD+ biosynthesis, suppressed age-related adipose tissue inflammation, enhanced insulin secretion and insulin action, improved mitochondrial function, improved neuronal function in the brain, and more. Here, we look at the science behind NMN, its stability, possible pharmacokinetics, transport, function, and ability to induce biosynthesis of NAD+. Supplementing NMN may be an effective nutraceutical anti-aging intervention, with beneficial effects on a wide array of physiological functions.

Can NMN truly reverse aging? In a 2013 Harvard study, the Harvard scientists observed that “NMN was able to mitigate most age-related declines in mice,” and that “treatment of old mice with NMN reversed all of these biochemical aspects of aging.” The study concluded that “enhancing NAD+ biosynthesis by using NAD+ intermediates, such as NMN and NR (Nicotinamide Riboside), is expected to ameliorate age-associated physiological decline”.

This has precipitated dozens of studies since that are focused on investigating NMN supplementation to treat cardiovascular diseasediabetesobesitylife extension, cancer, Alzheimer’s disease, Parkinson’s disease, and many more.

2022 study on human subjects concluded that Oral Administration of Nicotinamide Mononucleotide (NMN) Is Safe and Efficiently Increases Blood Nicotinamide Adenine Dinucleotide (NAD) Levels.

Benefits of NMN supplements

There is preliminary evidence to suggest that NMN supplements may have the following potential benefits:

1. Anti-aging effects: Some studies have suggested that NMN may help improve cellular health, reduce oxidative stress, and potentially have anti-aging effects.

2. Improved insulin sensitivity: NMN has been shown to improve insulin sensitivity and glucose metabolism.

3. Improved cardiovascular health: NMN has been shown to improve cardiovascular function and reduce oxidative stress in the heart, which may help support overall heart health.

4. Enhanced exercise performance: Some studies have suggested that NMN supplementation may help improve exercise performance and recovery in animals.

Chromadex NMN Supplement Test Report: 64% of NMN Supplements Fail Tests

ChromaDex NMN Report (Oct 2021): Supplement manufacturer ChromaDex alleges that testing has revealed that more than half of NMN anti aging supplements being sold on Amazon contained almost none of the bioactive molecule.

ChromaDex markets TruNiagen, which is based on its branded Niagen ingredient, which is a form of nicotinamide riboside (NR), the form of nicotinamide that actively crosses into the cell to participate in the NAD+ pathway. Boosting this pathway, and thus maintaining cellular function at a lively, youthful level, has become a prominent theme in recent anti aging research.

Credit: ChromaDex

* The same distributor (SerumLab S&C International LLC) was listed on the product packaging from 10 of the 22 product brands.

Some researchers have argued that a transporter exists for NMN too, which is something that ChromaDex disputes. It claims that NMN must first be converted into NR in the blood before it can be used by the cells.

In the several years since the NMN transporter discovery was asserted, the NAD+ anti aging field has become crowded with NMN based supplements all seeking a piece of the pie created by ChromaDex and its competitor and one time customer Elysium. (The two companies have been locked in various patent infringement and breach of contract suits for several years.)

Last fall, ChromaDex obtained 22 samples of NMN products being sold on Amazon. Of these, 14 claimed to contain 500 mg of NMN. A further two products claimed 300 mg on the label; five claimed 250 mg and one product claimed 125 mg.

Only one of the 500 mg products came close to meeting label claim. It had 456 mg of NMN. All of the other 13 products in the 500 mg group either came in at below reporting limit (BRL, defined as less than 1% of the stated amount) or, in the case of 3 products, no NMN was detected at all.

Almost all of the rest of the products performed better, having at least 88% of the label claim. A lone 250 mg product was identified as BRL.

In summary, ChromaDex said that 64% of the products tested contained less than 1% of the stated amount of the active ingredient, which should give consumers pause, the company said.

"While this is a limited snapshot of the vast NMN finished product landscape, it does provide a glimpse into the high variability of product quality that is available... According to this study, the majority of the products one might purchase online contain such a small amount of NMN that there would be no clinical benefits achieved from the dose. Another concern with these adulterated products is that the actual contents are not known and could pose a risk to the user," the company said in a statement.

Editor's Note: In February 2022, another third-party investigation uncovered tens of thousands of fake supplements sold on Amazon. Many of these included NMN.

David Sinclair Supplements List

Keep in mind that to date, Dr. David Sinclair has made a point to not promote or endorse any supplement products. We compiled this list from interviews and books in which Professor David Sinclair mentions supplements he takes.

We don’t know if he still takes these supplements, or whether he takes additional supplements that are not included on this list.

For example, in his book Lifespan, he mentions on page 304 that he takes NMN and resveratrol every morning, often mixed in his yogurt.

Here is the summary list:
  1. Nicotinamide Mononucleotide (NMN), 1g per day, in the morning
  2. Quercetin and fisetin, 500 mg each, once per day, in the morning
  3. Resveratrol, 1g per day, in the morning
  4. Vitamin D3 and K2
  5. Spermidine, 1 mg per day, in the morning
  6. Metformin (prescription drug) 1 gram per day: 500 mg in the morning and 500 mg in the evening
  7. Statin (prescription drug) – taken since his early 20s due to family history of cardiovascular disease
  8. Low-dose aspirin – 83 mg per day
  9. Alpha lipoic Acid
  10. Coenzyme Q10
He is also a co-founder of a pharmaceutical company called MetroBiotech which has begun clinical trials with a special, crystalline form of NMN called MIB-626.

But this will presumably be for sale as a drug to treat specific medical conditions, if the studies show positive outcomes.

NR vs NMN Molecule

Pitting NR vs NMN against each other is, for now, somewhat of a moot point because the two molecules have never been studied side by side in humans. The biggest, and most obvious, difference between NMN and NR is size. NMN is simply larger than NR, meaning it often needs to be broken down to fit into the cell. NR (Nicotinamide Riboside), when compared to other NAD+ precursors (like nicotinic acid or nicotinamide) reigns supreme in efficiency.

But give NMN a new door, one it can fit through, and it’s a whole new game. This is where cellular transporters come into play. Transporters are proteins that are doors on the cell; they allow molecules to enter the cell without needing to chemically transform.

Research from Shin-ichiro Imai, M.D., Ph.D., a professor of developmental biology at Washington University in St. Louis, identified a transporter that allows NMN to get into the cell without converting to NR. The catch? The transporter is only on cells located in the gut of mice and only works in the presence of sodium ions. NR, however, has been shown to enter cells in the liver, muscle, and brain tissue of mouse models. To date there is not yet evidence that these mouse studies can be extrapolated to humans. But again, the two have never been matched up against each other in a way that can truly identify one as superior to the other.

As research grows, it is likely to become clearer that NMN and NR may have differing benefits depending on the part of the body and their use. Where NMN transporters are found, they could make one more preferable over the other. NMN has also been found to improve insulin activity and production which could help to accelerate metabolisms and make the body more glucose tolerant.

Stability and storage of NMN and NR

A stability analysis demonstrates NR is stable (does not undergo degradation) for up to six hours at room temperature and seven days at two to eight degrees Celsius. Regarding stability of NMN and NR, David Sinclair, PhD, A.O. of Harvard University says, “Make sure your NR and NMN is kept in the cold. If it’s just on the shelf and it’s not in a stabilized form, then it will degrade to nicotinamide, which is something you don’t want to take high doses of because we’ve shown in my lab many years ago that nicotinamide will inhibit the sirtuins, and PARP as well, and interfere with DNA repair.”

What Foods Contain NMN?

The aim of taking NMN supplements is to boost NAD levels. So you need to look out for foods that are rich in NAD precursors, not just NMN. As lots of different molecules can be converted to NMN, and then NAD.

• Vitamin B3 rich foods: Foods that are high in niacin (vitamin B3) can help increase NAD+ levels in the body. Good sources of niacin include yeast, beef liver, poultry, fish, and whole grains.

• Leafy greens: Leafy greens, such as spinach and kale, are rich in folate, which can help increase NAD+ levels in the body.

It is important to note that foods which are high in NAD precursors do not necessarily increase NAD or NMN levels. Despite having an abundance of NAD precursors in your diet, your cells can use these nutrients for other processes and may not use them to produce NMN and then NAD.

On the other hand, NMN supplements push your cells to produce more NAD which has been shown in several animal and a few human studies. 

NMN is available in vegetables (broccoli and cabbage), avocado, mushrooms, meat, and shrimp but trying to obtain sufficient through diet alone would be problematic. 

Study dosages have been about 50mg - 250mg and suggested that a 150 pound (68kg) human would require about 560mg per day. The difficulty is that you would have to eat about 100 pounds of edamame, 1,800 pounds of broccoli, or similarly impossible amounts of cucumber, cabbage, avocado, tomato, mushrooms, raw beef, or shrimp.

FAQs

What makes a good NMN supplement?

With so many different supplements on the market claiming to be the best, it's hard to know which one is worth investing in. Realistically, there are only a few things that really matter:

1. Purity

The best NMN supplements use 98% purity NMN. It's as simple as that, always look for this level and nothing less should make the cut. After all, it's obvious that we all want a supplement that contains as much of the active ingredient as possible.

2. Dosing

There is no official recommended dose of NMN. It's a relatively new supplement and most brands contain between 250mg - 750mg per serving which is based on the limited amount of research on this ingredient. David Sinclair openly says that he takes 1000mg of NMN a day which is a relatively high dose.

A recent study published in February 2023 tested daily NMN at doses of 300mg, 600mg, and 900mg over a 60-day period in healthy adults of 40-65 years old.

There were no side effects reported and they found that NAD levels increased in all of these doses. It's important to highlight this was a small study of only 80 individuals and the study only ran for 60 days so it's not clear what the long-term outcomes will be. There are a lot of unknowns when it comes to NMN dosing and you need to decide what feels right for you. (1 )

3. Quality

Quality is one of the more challenging things to determine when it comes to choosing an NMN supplement. Taking a close look at the supplement facts table is a good place to start. The best NMN supplements aim to keep the formula as clean as possible. They avoid ingredients like magnesium stearate, artificial fillers and ensure that the capsules are sustainably vegan. Look out for "other ingredients" on the product label and you'll quickly realize if you're looking at a high-quality NMN supplement or not.

How long does it take for NMN to start working?

There are a handful of studies that show taking NMN can boost NAD levels within a few weeks. A study we mentioned earlier saw a measurable rise in blood NAD levels after just 30 days.

In reality, NMN supplements are likely to boost NAD levels sooner than this.

But the time it takes for biological benefits to be seen is not yet known in humans. It's currently under investigation and more information will come out in the next few years.

Some people report having more energy and better skin, but most people won't actually 'feel' anything. It's more so that the benefits are occurring at a cellular level which you won't necessarily be able to consciously notice.

Is NMN just vitamin B3?

The answer to this question is now obvious from the above. NMN is vitamin B3 + sugar + phosphate. So it's not just vitamin B3. It's two steps further along in the chain.

At this stage, most people think that they'll just take Vitamin B3 and that will eventually form NMN. But the issue is that a lot of energy is required to go from vitamin B3 to NMN and our cells won't naturally go down this route.

What are the side effects of taking NMN supplements?

As with all things NMN related, there isn't much solid information on NMN side effects. There are only a handful of studies using NMN in humans. Side effects are seldom reported and doses up to 1000mg are generally well-tolerated.

For example, one study gave 250 mg/day of NMN for 10 weeks to 25 prediabetic women who were overweight or obese without any adverse effects. (2)

But this does not mean that you won't experience any side effects. As with any supplement, the risk of experiencing a negative reaction is always possible. So always discuss this with your physician, especially if you have any other medical conditions and taking any medicines.

Is NMN safe to take long term?

It's really important to understand that there are no long term studies into NMN supplementation. Most studies run for a maximum of a few months. So there's a big question mark over the safety profile of long term NMN usage.

Although no red flags have been raised with respect to NMN just yet, it's very early days. It will be years before we know if NMN is safe to take long term and which dose is best.

So you have to decide for yourself whether taking NMN supplements is worth it.

At what age should you take NMN supplements?

There's no hard and fast rule for when you should start taking NMN supplements.

Hardcore advocates of NMN will say the sooner the better!

NAD levels decline at different rates depending on what organ you're looking at. But it's generally believed that NAD levels drop by about 50% every 20 years.

So whether you're in your 30s or 70s, the question of when you should start taking NMN supplements is not relevant. If you've done your research and want to take

NMN supplements, the best time to start is arguably now.

Can NMN reverse wrinkles?

NMN supplements are not the magic elixir for youth. It's effects are largely seen on a cellular level and the majority of people won't visibly see any changes in their exterior appearance.

With that said, some people have reported smoother skin, fewer wrinkles and reduction in grey hairs. But it's not been properly proven in research studies and it could be a placebo effect.

It is also important to keep in mind that wrinkles are a natural part of the aging process, and are caused by a variety of factors including genetics, exposure to the sun and other environmental factors, and lifestyle choices such as smoking and poor diet.

It's best to think of NMN supplements as a longevity aid that works on a cellular level. Rather than taking them with the aim of having a more youthful appearance.

How can I increase my NMN naturally?

In your quest for the best NMN supplement, you may be thinking you also want to try and increase your levels naturally.

In reality, what you're trying to increase is your NAD levels. And NMN supplements are only one of many ways in which you can boost your NAD levels.

1. High intensity interval training

All exercise is good. But studies have shown that high intensity interval training (HIIT) is particularly good. It's not suitable for everyone because the intensity can have negative health implications for people with underlying conditions (for example heart arrhythmias). (3 )

HIIT can be achieved with many different types of exercise. For example:
- short sprint bursts followed by a light jog
- Spin classes (i.e short bursts of vigorous cycling followed by lower intensity cycling)
- HIIT classes (which involve various bodyweight exercises)

But even something like doing jumping jacks intensely or high knee raises at home achieves a similar effect.

The theory is that the bursts of high activity mimic "threat" or "danger" which would have been a frequent occurrence as humans evolved on the savannahs of Africa hundreds of thousands of years ago. And this activates certain longevity genes.

But there's a sweet spot because if it's pushed too far, HIIT can be damaging. So it's best to start after a discussion with your physician and a trainer to assess your level.

2. Fasting

Going for prolonged periods without any calories has been shown to activate genes that extend longevity at a cellular level. When food is scarce, the body is tricked into thinking that "hard times are coming". In other words, the cells start activating genes that increase NAD levels in preparation for the perceived hardship. (4 )

A common entry-level regimen is the 18:6 Intermittent fasting. Essentially, only eating in a 6-hour window and having no calories at all for 18 hours. Some people just opt to eat once a day and others fast for several days at a time.

The studies show that the more aggressive regimens have the most health benefits. But of course, it's extremely difficult to maintain and definitely not suitable for the majority of people. But the entry-level fasting regimens are not too challenging. As always, speak to your doctor first.

3. Heat and cold shock

You've probably guessed the theme by now. Your cells respond to stress by activating protective genes. So the same applies to heat and cold shock. For example, using ice baths.

Obviously, there's a fine line between experiencing health benefits and harm. Pushing any of this too far can have serious health consequences. So if you're thinking of trying any of the above, you really must speak to a trained professional to get advice on how to start.

Is NMN hard on the liver?

There is currently no evidence to suggest that NMN is harmful to the liver. In fact, some studies have suggested that NMN may have a positive effect on liver health, as it has been shown to improve insulin sensitivity and reduce oxidative stress in liver cells.

However, it is important to keep in mind that NMN is a relatively new molecule and more research is needed to fully understand its effects on the body, including its impact on the liver.

Which is better: NMN or resveratrol?

It's hard to compare NMN and Resveratrol as they are completely different compounds with unique properties. Professor David Sinclair is an advocate of both and takes them daily.

Resveratrol is a natural compound formed in various foods such as grapes, red wine, and some berries. It's an antioxidant and anti-inflammatory compound in its own right. It has also been shown to increase NAD levels indirectly by activating certain pathways which are different to how NMN works. 

In summary, NMN and resveratrol work differently and you can't directly compare them. That's why the best resveratrol supplements often combine these powerful ingredients together.

Why are NMN supplements expensive?

NMN supplements can be expensive for several reasons:

1. Production costs: NMN is a relatively new molecule and the production process can be complex and time-consuming, which pushed the price up.

2. Limited supply: NMN is not found in large quantities in natural food sources, and the demand for NMN supplements is growing, which has led to a limited supply and increased prices.

3. Quality control: High-quality NMN supplements should undergo rigorous testing and quality control measures to ensure purity and potency, which can also drive up costs.

Best NMN supplements - Final words

As human trials continue to demonstrate positive health benefits, NMN supplements are likely to become increasingly popular in the coming years.

To ensure that you are selecting the best possible NMN supplement, it is crucial to ignore marketing language and carefully review the supplement facts table. This will provide you with information on the ingredient quality and any unwanted additives, allowing you to make an informed decision and choose a high-quality NMN supplement.

While NMN is considered one of the most promising anti-aging ingredients, it is not the only one available. Other ingredients, such as Vitamin D3, Omega 3, Whole Food Vitamin C, Quercetin, Fisetin, and Spermidine, are also believed to have anti-aging properties.

For more details on other anti aging supplements, check out "10 Best Anti Aging Supplements 2024 - Evidence Based". This article is part of the Anti Aging series.


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