Top-Performing U.S. Stocks and Cryptocurrencies in 2024: Market Leaders and Trends

By Editorial Team -
The U.S. stock market has witnessed phenomenal growth in 2024, with several companies posting massive gains across different sectors. From artificial intelligence (AI)-driven tech stocks to high-growth healthcare and utility firms, investors have seen remarkable returns.

Ranked: The 20 Best-Performing S&P 500 Stocks (2005-2024)

This article explores the best-performing stocks and cryptocurrencies, highlighting key trends shaping the financial landscape.

Top Gainers in 2024: Best-Performing U.S. Stocks

1. TSS, Inc. (TSSI) – Leading the Surge

  • Stock Growth: +5,181.88%
  • Current Price: $15.74
  • Sector: Technology / Infrastructure
  • Key Driver: Increased demand for data center infrastructure and cloud services.

TSS, Inc. has outperformed all other stocks in 2024, posting an astonishing 5,181.88% increase. The company, specializing in data center infrastructure, benefited from the AI boom, which has driven higher demand for computing power and cloud storage.

Top Institutional Holders (source):

  • Palisades Investment Partners, LLC
  • Murchinson Ltd.
  • Citadel Advisors Llc 
  • Vanguard Group Inc 
  • Blackrock Inc. 
  • Value Aligned Research Advisors, LLC 
  • Evernest Financial Advisors, LLC 
  • Geode Capital Management, LLC 
  • Mesirow Financial Investment Management, Inc. 
  • New York State Common Retirement Fund

2. Monopar Therapeutics Inc. (MNPR) – Biotech on the Rise

  • Stock Growth: +2,511.33%
  • Current Price: $43.10
  • Sector: Healthcare / Biotechnology
  • Key Driver: Breakthrough advancements in oncology treatments.

Monopar Therapeutics' stock skyrocketed due to significant progress in its pipeline treatments, particularly in cancer therapeutics. Investor enthusiasm surged after positive clinical trial results, making MNPR one of the year's best biotech plays.

3. Palladyne AI Corp. (PDYN) – AI-Powered Gains

  • Stock Growth: +1,692.31%
  • Current Price: $9.32
  • Sector: Artificial Intelligence / Technology
  • Key Driver: Expanding AI applications in various industries.
As AI adoption continues to grow, companies like Palladyne AI have capitalized on the trend, providing innovative solutions in machine learning and automation. Investors have piled into AI stocks, making PDYN a massive winner in 2024.

Bitcoin (BTC) and XRP: Cryptocurrency Resurgence in 2024

Cryptocurrencies have played a significant role in 2024’s financial growth. As digital assets gain more mainstream adoption, investors are flocking to crypto as an alternative investment.

Bitcoin (BTC) – The Digital Gold Continues to Dominate

  • Price Surge: +180% YTD
  • Current Price: Over $75,000
  • Key Driver: Institutional adoption, Bitcoin ETFs, and increasing demand as a hedge against inflation.

Bitcoin has experienced a massive bull run in 2024, fueled by institutional investors pouring into BTC ETFs. Major financial institutions have recognized Bitcoin’s role as "digital gold," further driving demand.

XRP – Ripple’s Global Expansion Boosts Its Growth

  • Price Surge: +120% YTD
  • Current Price: Around $1.50
  • Key Driver: Regulatory clarity and growing adoption in cross-border payments.
XRP has rebounded strongly after gaining legal clarity in its case against the SEC. Ripple’s partnerships with major banks and payment providers have solidified its use case in global remittances.

Technology Stocks Leading the Market

NVIDIA Corporation (NVDA) – The AI Giant

  • Stock Growth: +171%
  • Sector: Semiconductors / AI
  • Key Driver: Strong demand for AI-driven computing chips.

NVIDIA has solidified its position as a market leader in AI-driven semiconductors. The increasing need for GPUs to power AI models and data centers has fueled NVDA’s massive rally, with analysts projecting further growth.

Applovin Corporation (APP) – Mobile Advertising Dominance

  • Stock Growth: +832.85%
  • Sector: Digital Advertising / Mobile Apps
  • Key Driver: Revenue growth and strong profit margins.

Applovin has benefited from the surge in mobile app advertising, with its revenue increasing by 66%. The company’s successful pivot toward AI-driven ad targeting has been a game changer.

Utilities and AI Infrastructure: A Hidden Gem

Vistra Corp. (VST) – Powering the AI Revolution

  • Stock Growth: +291.99%
  • Sector: Utilities / Energy
  • Key Driver: Increased demand for AI-powered data center electricity.

As AI-driven businesses expand, the demand for power has surged, making utility stocks a hot commodity. Vistra Corp has been one of the top beneficiaries, as hedge funds and institutional investors recognize the growing need for energy infrastructure.

Financial Sector Gains Momentum

American Express (AXP) – Consumer Spending Rebound

  • Stock Growth: +58.4%
  • Sector: Financial Services
  • Key Driver: Strong consumer spending and corporate earnings.

American Express has performed exceptionally well in 2024, thanks to increased spending on travel and luxury goods. As the economy continues to recover, AXP remains a top pick for investors.

Goldman Sachs (GS) – Investment Banking Resurgence

  • Stock Growth: +48.4%
  • Sector: Banking / Investments
  • Key Driver: Rising interest rates and strong deal-making activity.

Goldman Sachs has capitalized on higher interest rates and strong deal activity in private equity and IPO markets.

Key Takeaways: What’s Next for Investors?

Stock Market Trends

✅ Artificial Intelligence Boom – AI-related stocks have seen explosive growth, with companies like NVIDIA and Palladyne AI leading the charge.
✅ Healthcare Innovation – Biotech firms like Monopar Therapeutics have delivered strong returns due to groundbreaking research.
✅ Infrastructure & Utilities – As AI adoption grows, power companies like Vistra Corp have become essential players in the market.
✅ Financial Sector Growth – Rising interest rates and strong consumer spending have fueled gains in the financial sector.

Crypto Market Trends

✅ Bitcoin ETFs Are Driving Institutional Adoption – BTC has become a mainstream investment asset.
✅ XRP’s Utility Is Expanding – With legal clarity, XRP’s role in cross-border payments is growing.
✅ AI & Blockchain Integration – More companies are merging AI with blockchain for enhanced financial applications.

Final Thoughts

The U.S. stock market and cryptocurrency market have both experienced tremendous growth in 2024. With AI, digital payments, and decentralized finance (DeFi) shaping the future, investors should keep a close eye on emerging opportunities.

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