Xylitol Nasal Spray Prevents SARS-CoV-2 Infection

-
The sophisticated American consumer has grown accustomed to the gold-standard for drug and health products—the prospective Randomized, double-blind, placebo-Controlled Trial (RCT). Operation Warp Speed (OWS) was supposed to be a churning mill of large RCT’s to help the nation understand what conclusively is effective in the prevention and treatment of COVID-19. Unfortunately, after three years, has delivered failed products (remdesivir, baricitinib, molnupiravir, COVID-19 vaccines) and small inconclusive trials of products that doctors have found effective in practice including off-target generic antivirals and anticoagulants. OWS did not test simple, affordable, available prevention strategies. Fortunately such RCTs where done outside of the US and have brought us important findings.

Balmforth et al, conducted a prospective double-blind, placebo-controlled trial of a xylitol based nasal spray in the prevention of SARS-CoV-2 infection in exposed healthcare workers in two hospitals in Uttar Pradesh, India. Xylitol is known to have anti-infective and anti-inflammatory properties and is used in XLEAR nasal spray and anti-infective chewing gum to prevent dental caries. Balmforth found that SARS-CoV-2 infection confirmed by serology was 71% lower with xylitol compared to placebo [36 cases (13.1%) Vs 97 cases (34.5%); odds ratio [OR] 0.29 (95% CI; 0.18–0.45), p < 0.0001]. Fewer clinical symptoms were also seen in the test group [57 cases (17.6%) vs 112 cases (34.6%); OR 0.40, (95% CI; 0.27–0.59), p < 0.0001]. No harmful effects were associated with xylitol. 

A smaller study of xylitol nasal spray in mild COVID-19 cases demonstrated that persistent loss of smell may be eliminated with xylitol nasal spray during the acute congestion phase.



Balmforth D, Swales JA, Silpa L, Dunton A, Davies KE, Davies SG, Kamath A, Gupta J, Gupta S, Masood MA, McKnight Á, Rees D, Russell AJ, Jaggi M, Uppal R. Evaluating the efficacy and safety of a novel prophylactic nasal spray in the prevention of SARS-CoV-2 infection: A multi-centre, double blind, placebo-controlled, randomised trial. J Clin Virol. 2022 Oct;155:105248. doi: 10.1016/j.jcv.2022.105248. Epub 2022 Jul 25. PMID: 35952426; PMCID: PMC9313533.

I have been impressed with the RCTs of topical nasal sprays and gargles in COVID-19 far more than those with oral or intravenous drugs. Xylitol available as XLEAR in US pharmacies is one of several choices for local nasopharyngeal protection and treatment of COVID-19.

Sources and References:

Reposted from Peter A. McCullough’s Substack.

Related: Best Nasal Sprays for COVID-19

Comments

Post a Comment

Pages

Popular posts from this blog

Glutathione vs NAD: What's the Difference?

-
Image
What's the difference between glutathione and NAD? We will cover the essentials and explain about each of these nutrients below.  What is Glutathione? Glutathione or GSH (tripeptide of glutamic acid, cysteine, and glycine) is referred to as the body’s “master antioxidant” or the “mother of all antioxidants” because it is your body’s primary and most prevalent protector, found in all mammalian tissue. Types of Glutathione There is a lot of confusion about GSH and what makes an effective glutathione supplement. There are different types, different formulas, and a lot of different companies saying different things. L-Glutathione or Reduced Glutathione because it is the most commonly found, least expensive, and the true core behind other forms you will find. There is some debate whether L-Glutathione alone can be effective taken orally. The theory being the enzymes in your stomach break it down before it can ever reach the blood stream and become useful. Some  evidence  suggests using
Read more

Best 6 Retirement Villages in Malaysia 2024

-
Image
Are you thinking of finding the best retirement home  for your parents in Malaysia? The demand for retirement homes in Malaysia can only go up in view of the increasing number of senior citizens in need of retirement homes that are affordable with good quality related support services. Malaysia is one of the top 10 retirement destinations in the world, based on the  Annual Global Retirement Index for the year 2020 .  Malaysian cities are clean and modern, its public transport unrivalled, and its people the friendliest in Asia. And while other Asian countries offer great budget holidays, and some offer first-class vacations, Malaysia manages to cater extraordinarily well to both. Next, you may need to understand some of the retirement related jargons here. There are many related terms such as retirement village, retirement home, retirement resorts, old folks homes, nursing homes, dual-key etc. So that we are on the same page, let's stick to the terms as defined by the Malaysian Mini
Read more

How The Spike Protein Affects The Brain

-
Image
Brain fog, loss of taste and smell, fatigue, headache, encephalopathy (brain disease), anxiety, and even   psychosis —a broad range of neurological symptoms were brought to attention after the COVID pandemic, appearing in   long COVID   and   vaccine adverse events . These problems might be caused by a microscopic biomolecule—the spike protein. The spike protein is found in the SARS-CoV-2 virus and can be produced in the body via infection and mRNA vaccination. Both of these introductory mechanisms impact  multiple organ systems . One organ system of interest is the nervous system—the system responsible for controlling our bodily functions and communicating with the sensory world. In short—our brain. How Long COVID and mRNA Vaccines Are Related to Spike Protein Using animal models and cell culture methods, researchers have studied in depth the effects of the spike protein on the nervous system. Long COVID  is often associated with experiencing oxygen deprivation with severe infection,
Read more

Inland Revenue Board (IRB) warns against fake e-mail, SMS offering BR1M insurance service

-
PETALING JAYA: The Inland Revenue Board (IRB) has warned the public against e-mail or SMS offering a 1Malaysia People’s Aid (BR1M) insurance service, saying it has not issued any such messages.  In a statement on Friday, the board noted that there had been numerous enquiries from people who had allegedly received such messages offering a BR1M insurance service called i-BR1M  “IRB confirms that we have neither issued any e-mail nor SMS through any officer to any applicant or recipient,” read the statement.  The statement also asked for all those who have received the e-mail or sms to delete it and not provide the sender any feedback.  Public who would require further clarification can either visit the official BR1M website at https://ebr1m.hasil.gov.my or call 1-800-88-2716. http://www.thestar.com.my/News/Nation/2014/10/17/IRB-BR1M-insurance-service/ You may also wish to read: How to reply to scammers?
Read more

Is Long COVID Real?

-
Image
Long COVID continues to debilitate a significant number of U.S. adults — 7.5%, or 1 in 13, 1   are struggling with a range of symptoms that make up this complex condition. Among those who have had COVID-19, 11% say they currently have long COVID, 2   which often includes unrelenting fatigue, respiratory symptoms, neurological difficulties and joint or muscle pain, all of which may become worse after physical or mental exertion. 3 Long COVID symptoms share many similarities with post-jab injuries, and it's likely both are rooted in mitochondrial dysfunction. Now, however, there's a growing trend to label long COVID and injuries from COVID-19 shots "functional neurological disorders" (FND), making some patients feel like the medical community thinks their symptoms are "all in their head." Is Long COVID Akin to 'Hysteria'? In an article for TNR, journalist Natalie Shure writes, "The most direct precursor to FND is something you've probably hear
Read more

Soybean Oil Linked to Genetic and Neurological Damage

-
Image
Far worse than the biologic damage caused by refined sugar is the molecular havoc caused by processed vegetable oils. Soybean oil in particular has a questionable safety profile for several reasons, and processed foods are positively loaded with it. Whether partially hydrogenated, organic or genetically modified to be low in linoleic acid, soybean oil can cause dysfunction at a cellular level. Unfortunately, many health authorities have insisted omega-6-rich vegetable oils like soybean oil are healthier than saturated animal fats such as butter and lard, and this myth has been a tough one to dismantle, despite the evidence against it.   An estimated 94% of the soybeans grown in the U.S. are genetically engineered (GE) to tolerate herbicides, 1  primarily glyphosate (the active ingredient in Monsanto/Bayer's Roundup), which cannot be washed off. As a result, most soybean-based products are contaminated with glyphosate, which compounds their toxicity. Soybean
Read more

10 Government Grants for Small Business Malaysia

-
Image
Battered and bruised by the COVID-19 pandemic, the nation’s small and medium enterprises (SMEs) have suffered from decreased sales revenue and tightened cash flow. They have faced a lack of labour and difficulties in adopting technological solutions to digitalise their business. As such, the RM14.2 billion in funds available for SMEs in Budget 2022 is “like a lifeline” for SMEs,  said  Universiti Malaya senior economics lecturer Goh Lim Thye. “They will be able to solve their cash flow problems with these grants.” With the pandemic proving just how important it is for businesses to have an online presence, Goh said the RM200 million digitalisation grant would be especially useful as it would encourage SMEs to explore such opportunities for their businesses. Out of the RM200 million, RM50 million has been set aside to digitalise Bumiputera micro entrepreneurs in rural areas. Goh noted how the online shopping boom has seen platforms such as Lazada and Shopee generate massive sales over t
Read more

12 Best SME Business Loans in Malaysia 2024

-
Image
SME or also known as Small and Medium-sized Enterprises are businesses that maintain revenues, assets, or a number of employees below a certain threshold. These business entities are often regarded as the heartbeat of Malaysia’s emerging and developing economies. Apart from providing vast numbers of employment opportunities, SME businesses are generally entrepreneurial in nature, helping to shape innovation. Generally, there are two criteria to be met in order for your business to qualify as an SME -- your annual sales turnover and the number of full time employees in your company. This also implies differently for each economy sector: Manufacturing (Small SMEs) Sales turnover RM300,000 to < RM15 million Full time employees 5 to < 75 people Manufacturing (Medium SMEs) Sales turnover RM15 million to < RM50 million Full time employees 75 to < 200 people Services & Others   (Small SMEs) Sales turnover RM300,000 to < RM3 million Full time employees 5 to < 30 people Se
Read more

RSS Feeds: What You Need to Know (2024)

-
In an era dominated by social media algorithms and curated news feeds, the humble RSS feed often finds itself relegated to the sidelines, dismissed as a relic of the internet's past. However, far from being outdated and irrelevant, RSS feeds actually remain one of the most powerful tools for staying informed in the digital age. It is likely they have been intentionally deemphasized because they are a legitimate threat to those in power as they allow you to circumvent media censorship. RSS, or Really Simple Syndication, allows you to curate your own news sources and tailor your information intake to your personal preferences. I suspect its lack of popularity stems not from inefficiency, but from the fact that RSS poses a very real threat to the gatekeepers of information. Hence its use is no longer encouraged by the media establishment the way it used to. Harnessing the power of RSS feeds empowers you to break free from the constraints of curated propaganda so that you can access th
Read more

How to choose the right MBA in Malaysia?

-
Image
If you have decided that it's time for you to put another feather in your corporate cap with an MBA , please continue reading. Image via Projectation.com So, how do you decide on which MBA to choose? Firstly, you need to understand the many types of MBA programs available. It can be really overwhelming when you try to do your research in the cyberspace. There are several different types of MBA programs in Malaysia . Not every business school offers every type, but most schools do offer at least one of more of the following: Two-Year MBA Programs  - Also known as full-time or traditional MBA programs, two-year MBA programs take approximately two years to complete. They are designed for students who are able to devote themselves to full-time study. If you are an working adult who cannot afford to take a two year break from your career, then this is not for you. One-Year MBA Programs  - One-year MBA programs, or accelerated programs as they are sometimes known, are rigoro
Read more